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, is a G protein-coupled cannabinoid receptor located primarily in the central and peripheral nervous system.

It is activated by the endocannabinoid neurotransmitters anandamide and 2-arachidonoylglycerol (2-AG); by plant cannabinoids, such as the compound THC, an active ingredient of the psychoactive drug cannabis; and by synthetic analogues of THC.

Modeling and analysis of genetic regulatory networks is essential both for better understanding their dynamic behavior and for elucidating and refining open issues.

We hereby present a discrete computational model that effectively describes the transient and sequential expression of a network of genes in a representative developmental pathway.

In cooperation with researchers from Osaka City University and the University of Tokyo, researchers at Osaka University, through their precise measurement of current fluctuations in quantum liquids in an artificial atom created by nanotechnology, succeeded in elucidating theoretically-predicted behavior of quantum liquid in a non-equilibrium regime.

Quantum liquids are macroscopic ensembles of interacting particles dense enough for quantum statistics to manifest itself.

Histologically, the skin lesions showed that the keratinocytes had necrosed and the epidermis was thin in some areas.

Obvious inflammatory cell infiltrations were not detected.

The computational results were verified experimentally by deleting various genes and by changing initial conditions.

Immunohistochemically, we stained each skin lesion against CD3, CD8, CD45RO, cytokeratin, 70 k D heat shock protein, ubiquitin, 150 k D oxygen regulated protein, and caspase-cleaved keratin 18 neo-epitope M30.

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(right) In a many particle system, on the other hand, the particles interact each other in a quantum mechanical way and behave as if they are "liquid".

This is called quantum liquid whose properties are very different from that of the single particle case.

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