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Histamine is a natural substance, one of the important inflammatory mediators produced in certain cells in the body.(20) When introduced into the nose, histamine causes dilatation and leakage of blood vessels.Many people find the worst symptom of their eczema is severe itching.Scratching relieves the itch, but also makes the inflammation and the itching worse because it causes more inflammatory substances to be released within the skin.Cold treatments recommended in have been properly tested and found to be effective.Their side effects are known and are acceptable for treating a mild illness like a cold.Antihistamines are medicines that can be used to relieve severe itching and help break this cycle.

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All are efficacious in controlling symptoms of allergic rhinitis (ie, sneezing, rhinorrhea, itching) but do not significantly improve nasal congestion.

When you get injured or your immune system detects a potentially dangerous foreign substance, certain white blood cells and tissue cells release histamines that seek out and attach to other cells that have a histamine receptor.

Here, the histamines induce an inflammatory response — they dilate the blood vessels, increasing blood flow to the site of injury or invasion.

In these conditions they work by preventing the actions of histamine, which is a substance produced by the body as part of its natural defences.

It's stored in cells called mast cells, in almost all tissues of the body, and is released when the body reacts to a foreign substance (known as an allergen).

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