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Their main benefit is they primarily affect peripheral histamine receptors and therefore are less sedating.

Itching, sneezing, and inflammatory responses are suppressed by antihistamines that act on H1-receptors.

Antihistamines are used in the treatment of allergic reactions, colds, hay fever, hives, and insect bites and stings.

Some antihistamines may also be helpful in reducing anxiety, inducing sleep, or at preventing or treating motion sickness.

Results of a radiolabeled tissue distribution study in rats and a radioligand H1-receptor binding study in guinea pigs showed that desloratadine did not readily cross the blood brain barrier. Dosing: Oral: Children: 6-11 months: 1 mg once daily 12 months to 5 years: 1.25 mg once daily 6-11 years: 2.5 mg once daily Children /= 12 years and Adults: 5 mg once daily Supplied Syrup (Clarinex®): 0.5 mg/m L (480 m L) [bubble gum flavor] Tablet (Clarinex®): 5 mg Tablet, orally-disintegrating (Clarinex® Redi Tabs®): 5 mg [contains phenylalanine 1.75 mg/tablet] Adult (usual) Chronic idiopathic urticaria: 60 mg orally twice daily.

Seasonal allergic rhinitis: 60 mg orally twice daily or 180 mg once daily.

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