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Finally, temporal trends in overall and individual OAC (warfarin and NOAC) use by sex were assessed.

Understanding these relationships can determine the influence of the CHA PINNACLE Registry consists of consecutive patients from cardiology practices in the United States that voluntarily participate and submit data as part of a national office‐based cardiovascular quality improvement program.21, 22 Data are collected at the point of care using a validated electronic medical record‐mapping algorithm for patients with hypertension (HTN), coronary artery disease, congestive heart failure, and AF.23, 24 Registry data quality is maintained through data definitions, standard data collection and transmission, and periodic data quality checks.23, 24, 25Between May 1, 2008 and December 31, 2014, 848 931 patients with their first documented AF diagnosis within the registry were identified.

The pediatric intensive care unit (PICU) has become a workplace with a high diversity of multidisciplinary physicians and professionals.

Therefore, delivery of high-quality care with optimal patient safety in a PICU is dependent on effective interprofessional team management.

Extracellular vesicles, such as exosomes, are important effectors in the formation of tumour-fostering niches.

Pigmented melanosomes are now shown to have a relevant role in establishing a tumour niche in primary melanoma by reprogramming dermal fibroblasts into cancer-associated fibroblasts through the transfer of mi R-211.

Full Text While the beneficial versus detrimental implications of the senescence-associated secretome remain an issue of debate, time-resolved analyses of its composition, regulatory mechanisms and functional consequences have been largely missing.

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To assess the impact of these advancements on OAC use in female AF patients, we examined the association of individual thromboembolic risk factors with OAC use in the National Cardiovascular Data Registry (NCDR‐VASc scores, controlling for estimated bleeding risk.Nevertheless, ineffective interprofessional teamwork remains ubiquitous. Methods: We based our review on the framework for interprofessional teamwork recently published in association with the UK Centre for Advancement of Interprofessional Education.Articles were selected to achieve better understanding and to include and translate new ideas and concepts.Findings: The barrier between autonomous nurses and doctors in the PICU within their silos of specialization, the failure of shared mental models, a culture of disrespect, and the lack of empowering parents as team members preclude interprofessional team management and patient safety.A mindset of individual responsibility and accountability embedded in a network of equivalent partners, including the patient and their family members, is required to achieve optimal interprofessional care.

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