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Resistance, in the first criterion, does not necessarily mean that the prebiotic is completely indigestible, but it should guarantee that a significant amount of the compound is available in the intestine (especially the large bowel) to serve as a fermentation substrate.Although each of these criteria is important, the third is the most difficult to fulfill.Prebiotics are a promising way to shape our gut microbiota (the term used for the total community of microbes colonizing your body) to be healthier for us.However they are not an alternative to a diverse healthy diet.However, more clinical evidence is needed to strengthen these proposals.

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Probiotics and/or prebiotics could be used as alternative supplements to exert health benefits, including cholesterol-lowering effects on humans.Everywhere you look there is an article or podcast or TED Talk about how important our colonizing microbes are to our health.But, like the weather, although everyone is talking about it what can we do about it?Past studies showed that the administration of probiotics and/or prebiotics are effective in improving lipid profiles, including the reduction of serum/plasma total cholesterol, LDL-cholesterol and triglycerides or increment of HDL-cholesterol.However, other past studies have also shown that probiotics and prebiotics had insignificant effects on lipid profiles, disputing the hypocholesterolemic claim.

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